A resilient 9-man Leyton Orient were beaten 2-0 at home to top of the table Plymouth Argyle, at The Matchroom Stadium.
Orient were reduced to 10-men in the opening minute, as Captain Robbie Weir was given a straight red for a late challenge.
The away side took the lead early on, as Jimmy Spencer slotted in for the visitors with Orient reduced to ten.
The evening then got even more difficult for the ‘O’s, as Jens Janse was sent off for a mistimed tackle on Jake Jervis as the last man.
Plymouth then grabbed their second late in the second half, as substitute Ryan Donaldson’s strike extended their unbeaten run to eight games.
Caretaker manager Andy Edwards first game in charge saw two changes to his side that were defeated 3-1 away at Notts County. Sandro Semedo and Jens Janse made his debut for the club ahead of Harry Cornick and Yvan Erichot who both moved to the bench.
Orient looked to overturn their back-to-back defeats against top of the table Plymouth who were on a seven game unbeaten run.
Within the first 30 seconds of the match Captain Weir was given a straight red deemed by referee Charles Breakspear for a late tackle on the Plymouth midfielder.
Orient then found themselves behind 13 minutes in, from the first real attack of the game as Spencer was played through inside the box and tucked it past Alex Cisak.
The home side were forced into a change, as Liam Kelly came off with an injury for Nigel Atangana.
Shortly after the restart, Orient went down to nine men as debutant Janse made a miss timed challenge on Jake Jervis out on the left hand side. The referee also sent him off due to him being the last man, as well to leave Orient with an uphill struggle.
Plymouth’s David Goodwillie made an off the ball challenge on defender Tom Parkes, as Cisak collected but the referee just gave the forward a talking too.
Goodwillie missed an unchallenged header inside the box for Plymouth to double their lead, who were enjoying the majority of possession.
In the second half, substitute Atangana was also forced off injured and had to be replaced by Harry Cornick.
Plymouth put the ball into the net for a second time but Goodwillie’s goal was disallowed for offside.
Cisak kept Orient in the match with some superb stops, to give the home fans some hope with time running out.
Although Plymouth secured the three points with six minutes to go, as substitute Donaldson slotted in from a cut back inside the box to put the nail in Orient’s coffin.
Leyton Orient Lineup: 1 Alex Cisak, 3 Callum Kennedy, 4 Liam Kelly, 6 Tom Parkes, 8 Robbie Weir ©, 10 Paul McCallum (82), 11 Gavin Massey, 16 Nicky Hunt, 22 Sandro Semedo, 27 Jay Simpson, 46 Jens Janse.
Substitutes: 24 Sam Sargeant, 9 Ollie Palmer, 15 Nigel Atangana (13) (48), 18 Ulrich Nnomo, 20 Harry Cornick (48), 21 Jordan Bowery (82), 25 Aron Pollock
Plymouth Argyle: 23 Luke McCormick ©, 2 Gary Miller, 4 Yann Songo’s (57), 5 Nauris Bulvitis, 6 Connor Smith (77), 7 David Goodwillie, 9 Jimmy Spencer, 10 Graham Carey, 14 Jake Jarvis, 15 Sonny Bradley, 16 Ben Purrington
Substitutes: 8 Jordan Slew, 11 Ryan Donaldson (77), 18 Oscar Threlkeld, 21 Vicent Dorel, 22 David Ijaha, 24 David Fox (57), 27 Craig Tanner (74)